Its a dual core i3 at 2.53 GHz. The slowdown did not refer directly to the controlport settings, just to VICE in general - but it appears to be an OS or h/w problem for sure. Old VICEs occassionally dropped massively in their performance as well, albeit not so fast at 3.0, it seems.
I have VICE on my D drive, but I tried copying it to other locations on C as well, including to Program files - to no avail.
r27549 Resid-FP has been removed. To compensate for the missing SID-Type selection, GUI items (slider) should be added for the following Resources: SidResidPassband (0..90), SidResidGain (90..100), SidResidFilterBias (-5000...5000)
The mouse emulation does work for me now - as it is intended, switching off the Win mouse pointer. But that is in AP 1.8 with 1351 emulation. Maybe the problem is with the Amiga mouse emulation?
With the file attribution, rebooting didn't help unfortunately - I am sure it is some small thing, but I can't seem to figure it out. :-/